1. Kinase Inhibitors
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Inhibitors targeting major signaling pathways such as:
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PI3K/Akt/mTOR, MAPK/ERK, JAK/STAT, EGFR, CDK, BCR-ABL, etc.
2. Anti-Cancer Compound Libraries
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Collections of bioactive compounds for screening
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Suitable for high-throughput screening (HTS)
3. Apoptosis & Cell Cycle Modulators
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Compounds that regulate cell death or cell cycle arrest
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Examples:
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Z-VAD-FMK (pan-caspase inhibitor)
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Nocodazole (microtubule depolymerizing agent)
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Nocodazole (microtubule depolymerizing agent)
4. Autophagy Modulators
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Inducers and inhibitors of autophagy pathways
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Widely used in cancer and neurodegenerative disease research
5. Metabolism & Diabetes-Related Compounds
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Agents that modulate metabolic pathways, such as:
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AMPK activators, GLUT inhibitors, etc.
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Examples:
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Metformin
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2-Deoxy-D-glucose
6. Immunology & Immune Checkpoint Inhibitors
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Compounds targeting immune pathways like:
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PD-1/PD-L1, CTLA-4, T-cell regulators, etc.
7. Antiviral & COVID-19-Related Compounds
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Inhibitors against SARS-CoV-2 targets like:
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3CLpro, PLpro, RdRp
8. Epigenetic Modulators
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Inhibitors of enzymes such as:
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HDAC, DNMT, BET, HMT, etc.
9. PROTACs (Proteolysis Targeting Chimeras)
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ARV-110 – targets androgen receptor
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dBET1 – BET bromodomain degrader
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MZ1 – BRD4 degrader
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PROTAC BRD4 Degrader-1